Abstract

CARDIO-PROTECTING AND ANTIOXIDANT ANALYSIS OF MORINDA LUCIDA IN AUGMENTIN TRIGGERED HEART DAMAGE: EXPERIMENTAL WISTAR RATS MODEL

Erigbali P. P.*, Egbejimi A. M., Sule O. J., Pepple V. and Sampson

ABSTRACT

Investigators set out in this research to understudy how rats inflicted with experimental heart injury will respond to pretreatment with a medicinal plant extract. In experimentally designed groups of randomly placed rats; test groups were inflicted with heart injury and treated with graded doses of Morinda Lucida, to see if they will respond differently from positive control group (inflicted with heart injury but not treated with the medicinal plant). Established method of assay for oxidative stress biomarkers of heart function/injury and antioxidant enzyme activities was then implored. Results presents the extract of Morinda lucida to have caused significant (p < 0.05) dose-dependent restoration of various cardiac function and oxidative stress markers. Based on the findings from the investigation, it can be
inferred that Morinda lucida exhibits notable cardioprotective attributes which is likely attributable to the antioxidant capacity inherent in the medicinal plant extract.

Keywords: Morinda Lucida, augmentin, antioxidant enzymes, oxidative stress, cardioprotective.