Abstract

PREPARATION AND EVALUATION OF FLOATING TABLETS OF MONTELUKAST SODIUM

Sandip V. Jadhav*, Manjunath G. Mukkane, Bhimashankar K. Bhui, Sakshi S. Hotkar, Satyajeet A. Gorave and Sujit A. Jamadar

ABSTRACT

The new formulation, which contains montelukast sodium for the management of persistent asthma, was created by creating floating tablets using various combinations of natural and synthetic polymers. The seven formulations of floating tablets of montelukast sodium are created using hydroxyl propyl methyl cellulose, guar gum and xanthan gum, where sodium bicarbonate and citric acid are employed as an effervescent ingredient. The tablets were made utilizing the direct compression method. The created tablets were tested for thickness, weight variation, hardness, friability, and further, all formulations were put through a 24-hour in-vitro release test using 0.1 N HCL. All of the formulations performed well in pre-formulation investigations. The kind of polymer employed in
the formulation will determine how quickly a drug will be released from a tablet. The release of montelukast sodium from the floating drug delivery system is observed to be inhibited by the viscosity of the polymer, which increases. The f3 formulation outperformed all others in terms of extended release over a 24-hour period. It demonstrated a release of 98.40% ± 0.10, making it the best formulation. The best formulation, f3, was then subjected to stability tests under the conditions of 40°C/75°RH, and the results indicated no significant changes after three months.Floating tablet, HPMC K15M, Guar gum, Montelukast sodium, Gum Xanthan.

Keywords: Floating tablet, HPMC K15M, Guar gum, Montelukast sodium, Gum Xanthan.