Abstract

EXPLORING DOPAMINE SILVER NANOPARTICLES: SYNTHESIS, CHARACTERIZATION OVER NEUROCHEMISTRY

Saroja R.*, Priyadharshini D., Sathish Kumar A. and Niraimathi V.

ABSTRACT

This study explores the synthesis and characterization of dopamine silver nanoparticles (AgNPs) along with the analysis of dopamine's properties and degradation pathways. Dopamine, a crucial neurotransmitter in the brain, undergoes degradation facilitated by enzymes, yielding homovanillic acid (HVA) as the primary end-product. Despite its significance, challenges persist in estimating brain dopamine activity due to overlapping metabolism with norepinephrine, particularly in schizophrenia research. Dopamine degradation involves enzymatic oxidation and direct reaction with oxygen, potentially contributing to cell loss in neurological disorders. The dopamine system's regulation and transportation into synaptic vesicles are governed by common mechanisms shared among neurotransmitters. The study introduces a novel synthesis method for dopamine silver nanoparticles, characterized using UV-Vis spectroscopy, scanning
electron microscopy (SEM), and transmission electron microscopy (TEM). Additionally, IR spectral studies provide insights into the molecular structure of the synthesized compounds. Thin layer chromatography (TLC) analysis confirms the presence of dopamine using a specific mobile phase. UV-Vis spectroscopy reveals distinct features indicative of the stability and size of the Ag nanoparticles, with sharp and high peaks suggesting well-defined plasmon resonance properties. The position and intensity of the surface plasmon resonance (SPR) peak correlate with the concentration and abundance of the nanoparticles in the solution. Overall, this study sheds light on the synthesis, characterization, and properties of dopamine silver nanoparticles, offering valuable insights into their potential applications in various fields, including medicine and nanotechnology.

Keywords: Dopamine, Silver nanoparticles, Dimethoxyphenethylamine, Characterization, Homovanillic acid.