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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL SUBSTITUTED BENZOXAZOLE DERIVATIVES

U. AbuMohsen

ABSTRACT

In this study, we aimed to synthesize some new benzoxazole derivatives bearing amide moiety and evaluate their antimicrobial activity. A set of seven novel compounds of 2-methyl-5-[4-(substituted-piperazin-/piperidin)acetamido]benzoxazole derivatives were synthesized by reacting 2-Chloro-N-(2-methylbenzoxazol-5-yl)acetamide with corresponding piperidine or piperazine derivatives in acetone. The structures of the final compounds were confirmed by spectral data (IR, 1H-NMR and MS). The antimicrobial activity of the compounds were determined by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds not exhibited remarkable activity.

Keywords: benzoxazole, amide, antimicrobial activity


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