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PROTECTIVE EFFECT OF ETHANOLIC ROOTS EXTRACT OF PSEUDOCEDRELA KOTSCHYI (PK) ON SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED DIABETIC RATS
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria. 2Department of Medicine, Faculty of Clinical Sciences, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria. 3Department of Physiology, College of Medicine, Ekiti State University, Ado- Ekiti, Ekiti, Nigeria, 4Department of Physiology, College of Health Sciences, Bingham University, Karu, Nasarawa, Nigeria. 5Department of Anatomy, College of Health Sciences, Bingham University, Karu, Nasarawa, Nigeria.
ABSTRACT This study investigated the effect of ethanolic roots extract of Pseudocecrela kotschyi on some hematological and biochemical parameters in alloxan-induced diabetic rats. Twenty- Five (25) wistar rats were randomly divided into five (5) experimental groups: control, diabetic, standard drug (glibenclamide) and Pseudocedrela kotschyi treated diabetic groups. The animals in four out of five groups were fasted for 18 h and were made diabetic by injecting with a single dose of alloxan (ALX) 150 mg kg-1. At the end of experimented period of 21 days (3 weeks), rats were sacrificed and blood samples were taken for the determination of glucose levels, red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), hemoglobin (Hb) concentration, and platelet count. Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), urea and creatinine levels significantly increased (p Keywords: Antioxidants, blood cells, hyperglycemia, rats, alloxan, Pseudocedrela kotschyi. [Download Article] [Download Certifiate] |
