Abstract

EVALUATION OF ANTI-ULCER ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF WHOLE PLANT OF BYTTNERIA HERBACEAE IN RATS

Bharathi K. N.* and Ankitha M.

ABSTRACT

The present study was carried out to evaluate the anti-ulcerogenic activity of aqueous and ethanolic extracts of whole plant of Bytteneria herbaceae against pylorus ligation model and ethanol-induced gastric mucosal damage in rats. Single dose of 200mg and 400mg/kg.b.w.p.o. of extracts were used in the study. The antiulcer activity was assessed by determining volume of gastric content, pH, total acidity, ulcer score, ulcer index and percentage protection in pylorus ligation model. Omeprazole (30 mg/kg) was used as standard drug. In the ethanol induced mucosal damage ulcer score, ulcer index and percentage protection was determined, sucralfate (100 mg/kg.b.w.p.o. was used as standard. Both aqueous and ethanolic extracts of whole plant of Byteneria herbaceae exhibited antiulcer activity as there was significant (p<0.001) reduction in ulcer score induced by pylorus
ligation model compared to negative control. Extracts also protected the mucosal damage induced by ethanol as there was significant (p<0.001) reduction in ulcer scores, ulcer index compared to negative control. Antiulcer activity of extracts were found to be dose dependent and ethanolic extract was more potent than aqueous extract in ethanol induced ulcer model. Presence of phytochemical constituents such as flavonoid, tannins, saponins, phenolic compounds and triterpenoids are responsible for anti-ulcer activity. Previous study of Bytteneria herbaceae have established antimicrobial activity against gram negative bacteria. This property further substantiates the use of Bytteneria herbaceae in the treatment of gastric ulcer.

Keywords: Peptic ulcer, pylorus ligation, ethanol, Bytteneria herbaceae