Abstract

UNRAVELING THE COMPLEXITY OF MIGRAINE: INSIGHTS FROM HISTORY TO MODERN PERSPECTIVE

Dr. Sethuramani A.*, Sasikumar A., Raxshiya Smily J. and Chandrasamy M.

ABSTRACT

Migraine, a neurological condition marked by intense throbbing headaches typically on one side of the head, along with symptoms such as nausea, sensitivity to light and sound, and vomiting, lacks a fully elucidated pathogenesis despite extensive study. Current knowledge indicates that there is activation of an intracranial network, which triggers sensitization of the trigemino-vascular system, release of inflammatory markers, and commencement of meningeal-like inflammatory reactions, resulting in the perception of headache. Globally, migraine ranks as the sixth most prevalent disease, imposing significant personal and socio-economic burdens due to its disabling nature. Sumatriptan succinate, the inaugural medication in the triptan family engineered for addressing acute migraine episodes, originally garnered attention due to its formidable capacity to constrict blood vessels in both animal and human subjects. While pharmacotherapies and psychological interventions remain crucial in conventional treatment, there has been growing interest in complementary and alternative therapies (CAM) for migraine management over the past two decades. Numerous studies exploring genetic factors associated with migraine have been conducted.

Keywords: Migraine, neurological condition, inflammatory markers, Prevalence, Sumatriptan succinate, Medicinal herbs.