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Abstract

LIPID PEROXIDATION, ANTIOXIDANTS AND HAEMATOLOGICAL CHANGES IN ALLOXAN-INDUCED DIABETIC RATS EXPOSED TO GENERATOR EXHAUST FUMES

1Ogugua V N٭, 2Egba S I, and 1Omaliko G I

1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
2Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

ABSTRACT

The possible effect of exposure to generator exhaust fumes on lipid peroxidation and some haematological indices in alloxan induced diabetic rats were studied. Test groups consist of normal rats exposed to fumes, diabetic rats exposed to fumes and diabetic rats not exposed to fumes. Normal rats served as normal control and were not exposed to fumes. The result of the study showed a significant increase in the level of Met-haemoglobin, Total white blood cell count and haemoglobin concentration in diabetic rats exposed to fumes compared to other test groups and the control. A significant increase (P<0.05) in lipid peroxidation and a general significant (P<0.05) decrease in catalase activity, vitamin C and glutathione concentration was equally observed in the exposed groups compared to non exposed groups. There was no significant difference (P>0.05) in Packed Cell Volume (PCV) and Red Cell Count (RBC) in test groups when compared to normal control group. The result of the study shows that the toxicity of exhaust fumes is increased in diabetes and further strengthens the general apprehension about the toxic effect and danger that exposure to generator fumes poses to the general public.

Keywords: Haematological, Lipid peroxidation, Alloxan, Methaemoglobin, Catalase, Glutathione.


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