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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF 2-IMINO-3-(4-METHOXYPHENYL) OXAZOLIDIN-4-ONE

Tesfahun Bufebo*, Aman Dekebo, Shilashi Badasa2 and Hanna Simion

ABSTRACT

2-chloro-N-(4-methoxyphenyl)acetamide synthesized by the reaction of 4-methoxybenzenamine with chloroacetylchloride in benzene were cyclocondensed with potassium cyanate in methanol to synthesize 2-imino-3-(4-methoxyphenyl) oxazolidin-4-one and Structure of the synthesized compounds was elucidated by using different spectroscopic techniques such as IR, 1H NMR, 13C NMR and elemental analyses. The purty of the intermediate and the product was checked by TLC plates, the reaction mechanism was given based on known site of functional groups. 2-chloro-N-(4-methoxyphenyl) acetamide was assayed in vitro by paper disc diffusion method for their antibacterial activities against Staphylococcus aureus bacteria, E.coil bacteria, the compound exhibit promising activity even better than standerd drugs against tested microorganisims

Keywords: Iminooxazolidinones, antibacterial, oxazolidinones, spectroscopic and elemental analyses.


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