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P.Manasa* and Mrs. S Srilatha


The main objective of this research work was to design and evaluate the bilayered tablets of paracetamol and chlorzoxazone by using different polymers. Paracetamol is an NSAID and chlorzoxazone is a skeletal muscle relaxant. The tablets containing immediate releasing layer and sustained release layer. The polymers used are microcrystalline cellulose pH 102, sodium starch glycol ate, cross carmellose, povidone for immediate releasing layer, HPMC K 100 cps, K4cps, E15cps, carbomer971P, and natural gums like guar gum, Xanthan gum for sustained drug release layer. The bilayered tablets were prepared by direct compression and wet granulation methods. All the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The Preformulation parameters such as bulk density, tapped density, compressibility index and Hausner’s ratio were analyzed. The In-Vitro drug release studied were Performed in the USP dissolution apparatus- (paddle) using pH 0.1N HCL buffer and pH 6.8 phosphate buffer as dissolution media at 100rpm speed and temperature of 37oC ± 5oC. The sampling was done at periodic time intervals of 2, 4, 6, 8, 10 and 12 hours and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV method. Based on the evaluation result the formulations F4 was selected as best formulation among immediate release and is used to compress with sustained release layer. Among all formulation F4 formulation (HPMC K100m18%) showed maximum release of 98.43% drug in 12th hour.

Keywords: Paracetamol and chlorzoxazone, sodium starch glycolate, HPMC K100m, K4M, dissolution studies, sustained release.

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