Abstract

COMPARATIVE ANTI-DIABETIC EFFECTS OF ETHANOL EXTRACTS OF NEWBOULDIA LEAVIS LEAVES AND STEM ON SERUM LIPID PROFILE AND LIPID PEROXIDATION STATUS IN ALLOXAN INDUCED DIABETIC RATS

Anaduaka Emeka G.¹, Ogugua Victor N.¹, Egba Simeon⃰ ² And Apeh Victor, O¹.

ABSTRACT

The plant kingdom offers a wide range of natural antioxidants and medicinal values. The antioxidant efficacy of the leaves and stem of the plant Newbouldia leavis were studied to ascertain the potential effects of the extracts on some biochemical indices. Diabetes was successfully induced in the test animals with 150mg/kg body weight alloxan monohydrate. There was a significant decrease (p<0.05) in blood glucose levels in the test animals when compared to the diabetes untreated (group 2) after day 7 with the exception of group 7 which showed no significance difference (p>0.05). There was also a significant decrease (p<0.05) in the blood glucose levels of test animals after day 14 with the exception of group 7 which showed no significant increase (p<0.05). The entire test groups showed significant decrease (p<0.05) with group 2 in day 14 in their blood glucose levels. Serum total cholesterol decreased significantly (p<0.05) in all the groups compared to group 2. There was significant increase (p<0.05) in the serum HDL in group 4 and 5 when compared to group 2, no significant difference was observed in group 7. Significant decrease (P<0.05) was observed in LDL in the test animals except in group 4 when compared to group 2. The lipid peroxidation product, malondiadehyde concentration (MDA) decreased significantly (p<0.05) when compared to group 2 with the exception of group 5 that showed no significant difference.

Keywords: Diabetes mellitus, Newbouldia leavis, Lipid profile, Lipid peroxidation.