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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF MEBEVERINE HYDROCHLORIDE USING NATURAL AND SYNTHETIC POLYMERS

A TarikaPriya*, M S Neeharika, Chandra K Sekhar

ABSTRACT

Antispasmodics relax the smooth muscles of the gut, helping to prevent or relieve painful cramping spasms in the intestines. The aim of the present study was to formulate and evaluate sustained release matrix tablets of Mebeverine Hcl using various natural and synthetic polymers to achieve high drug release control, reduce dosing frequency, increase bioavailability and increase patience compliance. The tablets were prepared by both wet granulation and direct compression methods. Preformulation and micromeritic studies of the drug, polymer and physical mixture were carried out. The matrix tablets were evaluated for pre-compression, post-compression studies and stability studies. The formulation FW1 showed satisfactory physical parameters and it was found to be stable among other formulations. The prepared tablets were found to be uniform with respect to thickness (2.16mm) and hardness (6.1kg/cm2). The friability (0.34%) and weight variation (297mg) of different batch of tablets were found within prescribed limits. Drug content (98.1%) was found uniform within the batches of different tablets. The kinetics of the dissolution process was determined by using various kinetic equations, e.g. Zero-order, First-order, Higuchi and Korsmeyer-Peppas equations. Based on kinetic models the formulation FW1(wet granulation) fitted into Zero order, First order, Higuchi model and Korsmeyer-Peppas plot and show non fickian diffusion mechanism release.

Keywords: Mebeverine hydrochloride, sustained release matrix tablets, matrix tablets formulation, evaluation, in-vitro release.


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