Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF SOME NEW BENZOIMIDAZOLE BASED TRIAZOLES

Upendra Pingili, Lingaiah Nagarapu*

ABSTRACT

Various novel 5-methyl-1-[2-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid benzylidene-hydrazides (5a-f) have been synthesized through condensation from 5-methyl-1-[2-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-1H-[1,2,3]triazole-4-carboxylic acid hydrazide (4) by suing 2-(2-bromo-phenyl)-1-methyl-1H-benzoimidazole (1) as raw material and by involving 2-(2-azido-phenyl)-1-methyl-1H-benzoimidazole (2) and 5-methyl-1-[2-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-1H-[1,2,3]triazole-4- arboxylic acid (3) as intermediates. The chemical structures of the newly synthesized compounds have been established by IR, 1H & 13C- NMR, Mass spectral data and elemental analysis. Further, the title compounds were used to screen for their ability towards various antibacterial and antifungal organisms.

Keywords: IR, 1H & 13C- NMR.