Abstract

SYNTHESIS AND CHARACTERIZATION OF 2-AMINO-4-(SUBSTITUTED QUINOLIN-3-YL)-7,7-DIMETHYL-5-OXO-5,6,7,8-TETRAHYDRO-4H-CHROMENE-3-CARBONITRILE SKELETON AND THEIR BIOLOGICAL SCREENING

Parth Barbhaya, Chandankumar T. Pashavan, Meet J. Sherashiya, Nilesh R. Kanzariya, Yogesh T. Naliapara*

ABSTRACT

An easy, effective method has been described for the Synthesis of 2-amino-4-(substituted quinolin-3-yl)-7, 7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The reaction between 2-((2-chloroquinolin-3-yl) methylene) malononitrile and dimedone in the presence of the MeOH as a solvent at reflux to give the desired final products. We have prepared a library of derivatives for their activities against used microbes and biological screening.

Keywords: Biological screening, Dimedone, Pyran quinoline, Methanol.