FORMULATION AND CHARACTERIZATION OF TRANSDERMAL PATCHES OF DULOXETINE HYDROCHLORIDE USING DIFFERENT COMBINATION OF POLYMERS BY SOLVENT EVAPORATION METHOD
G. Hariharaputhraayyanar*, K. Rajalakshmi, R. Sandhiya and K. Sneka
ABSTRACT
Background: Duloxetine Hydrochloride is used in the treatment of depression, diabetic peripheral neuropathic pain and moderate to severe urinary incontinence in women. Duloxetine Hydrochloride produces a toxic substance when its contact with gastric fluid. That the toxic substance named alpha-naphthol, which produces adverse effect in GIT. For this reason Duloxetine Hydrochloride available in market as delayed release capsules, enteric coated tablets. So, Transdermal Drug Delivery is selected as they increase bioavailability and improve patient compliance. The rationale of our study is to formulate transdermal patches of duloxetine hydrochloride in order to explore the feasibility of this route of administration to provide a once daily. TDDS is considered a good option for drug intended for chronic behavioural disorders like depression and anxiety as chance of patient non-compliance is very high with other routes of administration. The aim of the present study is to formulate Transdermal Patches of Duloxetine Hydrochloride using different ratio of polymers with and without adding copolymers such as HPMC K100 by Solvent Evaporation method.
Keywords: Evaporation method.
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