Abstract

LULICONAZOLE MICRO EMULSION-BASED GEL PREPARATION WITH NEEM OIL AND ASSESSMENT: A SYSTEMIC REVIEW

*Praveen Kumar, Madhav Mohan, Abhishek Bansal, Vipin Kumar Sharma, Vimal Singh, Tushar Cheetu

ABSTRACT

In the mod scenarios, dermatological diseases are increasing daily, and fungal infection playsplay a very important role. The fungal infections are severe and need eradication as quickly as possible. Luliconazole is a new antifungal drug along in combination with neem oil possess very effective anti-fungal action. However, for their quick absorption there topical preparation needs to be formulate. Micro emulgel formulation is a major breakthrough in the path of topical drug delivery system. One of the modern Novel Drug Delivery Systems used for controlled release is micro emulgel, which combines micro emulsion and gel. Micro emulgel has the potential to deliver both hydrophobic and hydrophilic drugs as a bi-fold controlled release. Due to the incorporation of gel in microemulsion, the stability is also enhanced and the cutaneous absorption of both types of drugs increases. Different excipients such as Aqueous phase, Oil Phase, Emulsifiers, Surfactants, Co Surfactants, Gelling agents and Permeation enhancers are incorporated in the preparation of micro emulgel. In addition to having a good appearance, the microemulgel formulation is thixotropic, graseless, easily spreadable, water soluble, emollient, non-staining, and has a longer shelf life. It is demonstrated to be thermodynamically stable as well. This paper describes how to create a luliconazole-based emulgel containing neem oil and assesses the effectiveness of luliconazole using metrics such as thickness, pH, conductivity, molecular size, Zeta potential, refractive index, physical appearance, consistency, and spreadability. This review opens the way for further investigation into the creation of cutting-edge micro emulgels.

Keywords: Luliconazole, Neem oil, Micro emulsion, Microemulgels, Topical Drug Delivery System, Hydrophobic drug, Anti-fungal Drugs.