Abstract

DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLETS OF BUSPIRONE HYDROCHLORIDE

Sundramoorthy K., Dheena S.*, Avinash R., Deivaraj S., Dhamodharan J. and Pravin S.

ABSTRACT

The present study was undertaken with an objective of formulating the mouth dissolving tablets of buspirone hydrochloride to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy. Various batches of mouth dissolving tablets of buspirone hydrochloride were prepared by direct compression method by using various concentration of Emcosoy® - Soy Polysaccharides, AmberLite™ IRP88 and L-HPC LH-22 with Microcrystalline Cellulose PH 102, Mannitol, Sunset Yellow, Citric acid, Orange flavor, Talc and Magnesium Stearate and evaluated for appearance, weight variation, thickness, hardness, friability, wetting time, drug content, disintegration time and in-vitro drug release. Among all the formulations, F6 (containing 10% of AmberLite™ IRP88) having a less disintegration time (22 seconds), highest drug release (98.73%) at 12 minutes. It can be concluded from the study that
the mouth dissolving tablets of buspirone hydrochloride, formulation F6 for mouth dissolving administration can be an optimized formulation is better and effective to meet patient compliance.

Keywords: Buspirone Hydrochloride, Emcosoy® - Soy Polysaccharides, AmberLite™ IRP88, L-HPC LH-22, Mouth dissolving tablets, Orodissolving tablets, Orally disintegrating tablets, Fast dissolving tablets, Disintegrants, Disintegration time, In-vitro drug release, Anx