Abstract

FORMULATION, DESIGN, DEVELOPMENT AND OPTIMIZATION OF ORAL OSMOTIC TABLET LOADED WITH LOSARTAN POTASSIUM USING FACTORIAL DESIGN

Poorva Mishra*, Dr. Revathi A. Gupta, Dr. Gaurav Jain, Jaydeep Singh Baghel, Shivagni Rathore

ABSTRACT

Osmotic tablets are a promising drug delivery system that provides controlled and extended release of drugs, ensuring optimal therapeutic effects while minimizing side effects. Losartan potassium, an angiotensin II receptor antagonist, is commonly used to manage hypertension and other cardiovascular conditions. This study aimed to design, develop, and optimize an oral osmotic tablet formulation of Losartan potassium using a factorial design approach. A 2x3 full factorial design was employed, with three independent variables: the concentration of osmotic agent, the level of pore former, and the amount of Losartan potassium. The dependent variables included drug release at various time points, tablet weight, and the integrity of the tablet shell. The results revealed that the selected factors significantly influenced the drug release profile and tablet characteristics. Utilizing the factorial design approach, an optimized osmotic tablet formulation was generated, and the desirability function was maximized. The optimized formulation demonstrated a well-defined and controlled drug release, meeting the desired release kinetics.in conclusion, this study successfully designed, developed, and optimized an oral osmotic tablet loaded with Losartan potassium using a factorial design. The developed formulation exhibits great potential for the controlled release of Losartan potassium, enhancing its therapeutic efficacy in the management of cardiovascular conditions. Further in vitro and in vivo studies are necessary to validate the clinical utility and bioavailability of the optimized osmotic tablet.

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