Abstract

FORMULATION AND EVALUATION OF NIOSOMES BY THIN FILM HYDRATION TECHNIQUES

Amol G. Jadhao*, Megha C. Kapare, Nageshwari S. Turukmane and Jayshri B. Sanap

ABSTRACT

The goal of this study was to see how well a topical niosomal gel containing Natamycin delivered the drug. The particle size, shape, entrapment efficiency, and in vitro properties of niosomal formulations generated using the thin film hydration process atvaried cholesterol and Span 60 ratios were investigated. The concept of drug targeting or site specific drug delivery was introduced first time by Paul Elrich in 1909, when he reported ‘magic bullet’ to deliver a drug to the desired site of action without affecting the non target organs or tissues (Juliano, 1980) by associating the drug with a pharmacologically “inactive carrier” capable of conveying the drug selectively towards its target cells. Span 20-based niosome was prepared by lipid film hydration technique and loaded with Newcastle disease vaccine. Etoricoxib is a potent new COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout arthritis etc. Two formulations were prepared by thin film hydration technique using the drug, cholesterol and surfactants Tween 80 (F1) and Span 60 (F2). Another two formulations were prepared by ether injection method using cholesterol and surfactants Tween 80 (F3) and Span 60 (F4). Each formulation was evaluated for drug content, entrapment efficiency, mean vesicular diameter, zeta potential and In-vitro drug release studies.

Keywords: Niosome, Sonicator, Film formation method, Multilamellar vesicles, In vitro drug release studies Nanoparticle.