Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DEVELOPMENT AND VALIDATION OF UPLC METHOD FOR DETERMINATION OF ATENOLOL IN TABLETS FORM

P.Ravi Kumar Reddy*, V. Krishna Reddy, E.Sasikiran Goud

ABSTRACT

A simple, sensitive and accurate isocratic reverse phase ultra performance liquid chromatography method was developed for determination of atenolol in formulations. The effective separation was achieved on Zorbax-C18, 50x4.6mm with particle size 1.8μm. The buffer and methanol in the ratio 70:30v/v used as a mobile phase. The buffer was prepared as 1.1g of sodium-1-heptanesulfonate and 0.71g of anhydrous dibasic sodium phosphate in 700ml of water. Add 2ml of dibutyl amine and adjust the pH to 3.0 with 0.8 M phosphoric acid. Filter through 0.22μm filter and degas. The flow rate of the mobile phase was 1.0mL/min and the total elution time was 2 minutes. The UV detection wavelength was carried at 226nm and experiments were conducted at 25°C. The developed method was validated in terms of system suitability, selectivity, linearity, precision, accuracy, limits of detection and quantification for determination of atenolol following the ICH guidelines.

Keywords: Atenolol, Method development, ICH and UPLC.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More