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Abstract

DEVELOPMENT AND VALIDATION OF UPLC METHOD FOR DETERMINATION OF CARVEDILOL IN CARVIDEX TABLETS

P. Ravi Kumar Reddy*, V. Krishna Reddy, E.Sasikiran Goud

ABSTRACT

A simple, sensitive and accurate isocratic reverse phase ultra performance liquid chromatography method was developed for determination of carvedilol in carvidex tablets. The effective separation was achieved on Hypersil BDS-C8, 50x4.6mm with particle size 3μm. The mixture of buffer and methanol in the ratio 65: 35v/v used as a mobile phase. The buffer was prepared as 2.72g of ammonium acetate in 1000 ml of purified water and adjusts the pH 2.0 with orthophosphoric acid. The flow rate of the mobile phase was 1.5mL/min and the total elution time was 2 minutes. The UV detection wavelength was carried at 240 nm and experiments were conducted at 50°C. The developed method was validated in terms of system suitability, selectivity, linearity, precision, accuracy, limits of detection and quantification following the ICH guidelines.

Keywords: Carvedilol, Method development, Hypersil BDS C8 and UPLC.


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