Abstract

REVIEW ON: TRANSDERMAL DRUG DELIVERY SYSTEM

Vaishali Arvind Dhurve*, Aishwarya Vijayrao Deshmukh and Vishnudas Kishan Lokhande

ABSTRACT

One crucial component of a revolutionary medicine distribution system is the transdermal drug delivery system. The drugs are applied topically as patches, which are patches that carry the medication to the skin. The medication for operational TDDS can readily pass through skin and arrive at the intended location. TDDS reduces gastrointestinal side effects, lowers dosage frequency, and prevents first pass metabolism. Stable and ideal blood concentration reduces the likelihood of adverse effects. It is a more effective medication in terms of bioavailability. Composed of several histological layers, the human skin is a multi-layered organ. In the human body, the skin is the biggest organ. Its primary roles include sensation, temperature management, water output control, and defence of important or crucial internal organs against external threats. Non-toxic, non-reactive to chemicals, and inexpensive are the qualities that make a polymer desirable. Examples include zein, gelatin, and compounds of cellulose. Protecting the active layer of the transdermal patch is the primary function of backing films. The basic components of transdermal drug delivery systems (TDDS) can be examined by interaction studies, thickness, weight uniformity, drug content, in vitro study, moisture content, and swelling index.

Keywords: TDDS, Peel adhesion, Shear strength.