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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Updated Version

WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

LONG-TERM EFFECTIVENESS AND SAFETY OF ENDOXIFEN IN THE TREATMENT OF ACUTE BIPOLAR MANIA: A CASE REPORT

Abhishek Chakladar, Nand Kumar*, Rohit Verma and Manmeet Kaur Brar

ABSTRACT

Antipsychotic drugs and mood stabilizers as mono or combination therapy are first-line agents in the treatment of the manic phase of bipolar I disorder. Endoxifen a potent inhibitor of the protein kinase C (PKC) signaling pathway, is efficacious in the control of acute bipolar mania, at doses of 8 mg, for a period of 3-weeks. However, there is a dearth of data about the long-term use of endoxifen. Here we describe a case of acute bipolar mania not able to tolerate clozapine therapy, efficaciously controlled with long-term use (9-weeks) of endoxifen8 mg, without any adverse effects, along with complete remission of manic symptoms.

Keywords: Endoxifen, Acute bipolar mania, Long-term use, safety, Effectiveness.

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