Abstract

SYNTHESIS AND EVALUATION OF SOME 1, 3, 4-THIADIAZOLES HAVING SUBSTITUTED 1, 2, 4-TRIAZOLE MOIETY FOR ANTICONVULSANT AND CNS DEPRESSANT ACTIVITY

*D.Kumudha, R.R.Reddy, T.Kalavathi

ABSTRACT

Some novel 4-([5-amino-1,3,4-thiadiazol-2yl) methyl)-5-substituted phenyl-4H-1,2,4-triazol-3-thiols (8a-d) have been synthesized from 5-substituted phenyl 4H-1,2,4-triazole-3-thiol(4a-d) using substituted benzoic acid hydrazides as starting material. The synthesized compounds have been characterized by spectral analysis and were evaluated for their anticonvulsant, CNS depressant activities and Neurotoxicity.

Keywords: 1, 3, 4-Thiadiazole, 1, 2, 4-Triazole, Anticonvulsant, CNS depressant, Neurotoxicity.