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Abstract

EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF ETHANOLIC EXTRACT OF STEM BARK OF GLYCOSMIS PENTAPHYLLA IN RATS

B.Vimochana* G.Sumalatha, Ch.Usha Rani

ABSTRACT

The objective of present study is to evaluate Antidiarrhoeal properties of Ethanolic extract of stem bark of Glycosmis pentaphylla in experimental castor oil induced Diarrhoea and castor oil induced enteropooling models in rats. The parameters assessed were decrease in frequency and severity in diarrhoea caused due to castor oil. In this study the phytochemical analysis of the ethanolic extract of Glycosmis pentaphylla revealed the presence of alkaloids, glycosides, tannins, flavanoids, sterols, saponins. The methanolic extract of Glycosmis pentaphylla showed significant reduction in frequency, severity and volume of intestinal content and intestinal transit compared to control group at doses 200mg/kg , 400mg/kg body weight orally. The experimental findings revealed that the ethanolic extract of Glycosmis pentaphylla showed significant antidiarrhoeal activity supporting its use in traditional practice.

Keywords: Glycosmis pentaphylla, Castor oil, Intestinal transit.


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