Abstract

THE EFFECT OF FEEDING MUCUNA OIL ON THE LIPID PROFILE AND CREATINE KINASE ENZYME OF ALBINO RATS

^1,2Omeh Yusuf S*., ²Ugwu Okechukwu P.C. and ²Enechi O.C.

ABSTRACT

The effect of feeding Mucuna oil on the lipid profile and creatine kinase level of albino rats were evaluated. Ten rats were randomly divided into two groups of five each. 10% Mucuna oil (MO) based diet (as the only source of fat) was fed to the group one rats while a control diet containing 10% Palm Oil (PO) (as the only source of fat) was fed to the group two rats. Feeding lasted for 28 days. At the end of the feeding, the total cholesterol, total lipids, high density lipoprotein (HDL), low density lipoprotein (LDL), triacylglycerol (TG) and serum creatine kinase levels were determined, using standard laboratory methods. Serum total cholesterol concentration (mg/100ml) significantly (P<0.05) decreased from 227.12±0.01 in PO group to 186.02±0.05 of MO group. HDL significantly (P<0.05) increased from 62.54±0.02 in the PO group to 121.71±0.04 of MO group. Total lipid significantly (P<0.05) decreased from 192.33±0.57 of PO to 165.33±0.28 of MO respectively. LDL values also decreased but not significantly (P>0.05) from 77.61±0.03 in P.O to 67.90±0.01 of MO. TG significantly decreased(p<0.05) from 163.31±0.03 of PO to 98.11±0.01 of MO and VLDL decreases from 55.75±0.03 of PO to 35.09±0.02 of MO respectively. Also the serum creatine kinase decreased significantly (p<0.05) from 124.33±1.16 in the control to 100.16±0.25 for the test group. These findings may be of clinical importance to individuals that are predisposed to cardiovascular challenges.

Keywords: Mucuna oil, lipid profile, creatine kinase, albino rats.