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Abstract

IN SILICO AND IN VITRO ANTHELMINTIC ACTIVITY OF STIGMASTEROL ? -D-GLUCOSIDE ISOLATED FROM RHIZOMES OF HEDYCHIUM SPICATUM BUCH. HAM.

Sravani T, Padmaa M Paarakh*, Shruthi SD

ABSTRACT

Hedychium spicatum Buch. Ham. (Zingiberaceae), commonly known as spiked ginger lily, is found in the entire Himalayan region. The rhizomes are reported to be used as tranquilizer, hypotensive, antispasmodic, CNS depressant, analgesic, anti-inflammatory, antimicrobial, antioxidant, antifungal, pediculicidal, cytotoxic and anthelmintic activities. The present study is an attempt to explore the anthelmintic activity of Stigmasterol β – D Glucoside isolated from the rhizomes of H.spicatum by molecular docking with tubulin and in vitro activity against adult Indian earthworms, Pheretima posthuma. The time taken for each worm for paralysis and death were determined. Stigmasterol β – D Glucoside binds very efficiently within the active pocket of tubulin which is better when compared to orientation of standard drug, Piperazine citrate. In vitro results correlated with the in silico studies. The time taken for paralysis and death with stigmasterol β – D glucoside at 40 mg/ml was comparable to standard Piperazine citrate.

Keywords: Anthelmintic activity, Stigmasterol ? – D Glucoside; docking, Hedychium spicatum, tubulin, Zingiberaceae


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