Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND EVALUATION OF TOPICAL FLURBIPROFEN GEL USING DIFFERENT GELLING AGENTS

Kokane Vikrant *, Naik Sonali 

ABSTRACT

Flurbiprofen is chemically 2-(3- fluoro-4-phenylphenyl) propanoic acid. It is non steroidal anti inflammatory agent used in the treatment of rheumatoid arthritis and osteoarthritis .Oral administration of this drug is associated with severe gastrointestinal side effects like ulceration and gastro intestinal bleeding. The solution of this problem lies in the fact that, topically applied NSAIDs are safer than oral NSAIDs. The objective of the study was to prepare gel of flurbiprofen using different gelling agents : carbopol 940, carbopol 934, hydroxypropylmethylcellulose and lutrol F-127.These preparations were further compared with marketed flurbiprofen gel.The gels were evaluated for physical appearance, pH, spreadability, extrudability,
rheological studies , drug content and in vitro release. All gel formulations developed contain ethanol & propylene glycol which in combination enhances permeability of gel. The gel containing lutrol F-127 as gelling agent is translucent and permeation studies of it were comparable with marketed gel.Drug content was found to be uniform in all the formulations. The pH ranges of formulated gels were found to be suitable for topical application. The accelerated stability studies were performed according to ICH guidelines for 3 months and the results were found to be stable in varying temperature.

Keywords: Flurbiprofen, lutrol F-127, carbopol, hydroxypropylmethylcellulose, topical gel.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More