Abstract

PREPARATION AND EVALUATION OF ORODISPERSIBLE FILM CONTAINING NONSTEROIDAL ANTI – INFLAMMATORY DRUG

Dani Kiran*, Revathi A. Gupta and Ranjeet Bargode

ABSTRACT

The aim of this study was to use the easily soluble model drug ibuprofen as a potential dosage form for children and the elderly as a rapid-release and The objective was to mechanistically develop and evaluate a sustained-release ODF formulation. Orodispersible films (ODFs) are a convenient and advanced dosage form that provide good drug delivery benefits to patients. In fact, they are the most innovative alternative to traditional dosage forms such as tablets and capsules. ODF is portable and very convenient for self-administration by patients with swallowing disorders. Orally disintegrating films or strips containing water-soluble polymers maintain their dosage form, are rapidly hydrated by saliva, and disintegrate within seconds after adhering to mucous membranes,dissolving and dissolving drugs when placed in the mouth. It is released and absorbed through mucous membranes. Oral film technology is an alternative route with first-pass metabolism. Orally disintegrating films (ODFs) are a new technology that enables “waterless formulations” with rapid onset of action and improved patient compliance. Therefore, oral film drug administration is a better alternative in such cases. Oral films consist of polymers, plasticizers, flavors, colorants, and sweeteners. Oral films are manufactured using solvent casting processes, rolling processes, extrusion processes and solid dispersion processes. Ibuprofen ODFs prepared using different film-forming materials showed satisfactory drug dissolution and acceptable physico-mechanical properties. Among the six formulations, the films prepared using HPMC E5 and PVP K30 exhibited the highest dissolution rate, adequate in vitro disintegration time, and satisfactory physicomechanical properties.

Keywords: Ibuprofen, anti-inflammatory drug, analgesic, mouth dissolving film, HPMC.