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Dipti Phadtare*, Ganesh Phadtare, Nilesh Barhate, Mahendra Asawat


Diclofenac Sodium is a potent non-steroidal anti-inflammatory drug with analgesic and antipyretic properties. Due to its low solubility in water and high permeability it is classified as BCS II. Diclofenac Sodium as a model drug is widely used to study the different dosage form. However, extended release systems prepared incorporating diclofenac sodium has received considerable attention. The main objective of the present work was to develop a extended release matrix tablet of Diclofenac sodium using hydroxypropyl methylcellulose (HPMC) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required extended release profile, 185mg tablets with different drug: hydroxypropylmethylcellulose (HPMC) ratio were formulated. Extended-release matrix tablets containing 75mg diclofenac sodium were prepared wet granulation. Formulated extended-release diclofenac sodium tablets were analyzed for in-vitro drug release. The results of the present study point out that Diclofenac sodium release from HPMC matrices are mainly controlled by the Drug:HPMC ratio as well as viscosity of HPMC . Drug release kinetics of this formulation correspond best to Zero order model and drug release mechanism swelling, polymer disentanglement and erosion based on release exponent value of Korsmeyer and Peppas equation.

Keywords: Diclofenac sodium; extended release; hydrophilic matrix; HPMC; wet granulation.

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