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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

EFFECT OF ETHANOL LEAF EXTRACT OF ALSTONIA BOONEI ON THE LIPID PROFILE OF ALLOXAN INDUCED DIABETIC RATS

1Enechi, O.C*., 1Oluka Ikenna H., 1Ugwu Okechukwu P.C. and 2Omeh Yusuf S.

1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
2Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria.

ABSTRACT

This work evaluated the effect of different doses of ethanol leaf extract of Alstonia boonei on the lipid profile of normal and alloxan- induced diabetic rats. The phytochemical analysis of the extract was also carried out. Glibenclamide was used as a reference standard drug at a dose of 2mg/kg body weight. The phytochemical results showed the presence of alkaloids, glycosides, flavonoids, tannins, saponins, steroids, and terpenoids. The extract had no effect on the elevated lipid profile of the treated diabetic rats compared to the normal and standard controls. However, Alstonia boonei extract lowered the High density lipoprotein of the diabetic test groups when compared with the normal control. These results show that ethanol extract of Alstonia boonei leaves are rich in phytochemicals and had no effects on the elevated lipid profile of the treated diabetic rats.

Keywords: Alstonia boonei, glinbenclamide, phytochemicals, lipid profile and diabetic rats.


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