Abstract

INCIDENCE AND SEVERITY ASSOCIATED WITH ADVERSE DRUG REACTIONS IN SURGERY PATIENTS

Mohasin S.*, S. Aswini, Shilpa S. K. and T. Pawan Kumar

ABSTRACT

An Adverse Drug Reaction is any undesirable effect of a drug beyond its anticipated therapeutic effect occurred during clinical use. ADRs are a major cause of morbidity and mortality. This was a prospective and observational study in which 165 subjects were enrolled based on the criteria and was evaluated by suitable statistical method. Among 165 patients, 89 (54%) female patients and 76 (46%) were males. A higher incidence of patients in the age group 60-100 (50%) was observed. Cephalosporin, NSAIDs and penicillin derivatives were the main medication classes that contributed to the occurrence of more ADRs in cases 59, 36 and 38 respectively. The most common ADRs reported by individuals were diarrhea and itching, with constipation, respiratory problems and the remaining symptoms occurring in extremely small numbers. The most commonly utilized medications for managing ADRs were loperamide (12%), hydrocortisone (12%), pheniramine (10%), and diethylcarbamazine (10%). The Naranjo scale revealed a larger causality reduction. Higher instances were generally
84.8% definite and 1.8% probable. Recovery rates were 93.33% along with 6.1% not entirely recovered. Result of study concluded that a higher incidence of ADR is reported with use of cephalosporin antibiotic in maximum number of subjects (59) out of total 165. Severity appears to be more moderate and less severe that concludes recovery rate is more (93.33%) with effective management. Present study concludes that ADRs are indeed a major drug related problems affecting outcomes and health related quality of life.

Keywords: Adverse Drug Reaction, Incidence, NSAIDs, Severity.