Abstract

REVIEW ON SOLID DISPERSION IN DRUG DELIVERY SYSTEM

*P. Bhavana and P. Venkata Anudeep

ABSTRACT

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have reduced the incidence of these problems and enhanced dissolution. The focus of this review article on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release solid dispersions can be formulated. Initially crystalline carriers were used which are transformed into amorphous solid dispersions with enhanced properties. The carriers used previously were mostly synthetic one. Recent trend towards the use of natural carriers have replaced the use of synthetic carriers. This review is an overview of various synthetic, natural, semisynthetic, and modified natural hydrophilic carriers used for the formulation of solid dispersions.

Keywords: Hydrophilic carriers, Mucilage, Natural gums, Solid dispersions, Solubility, Solubility enhancement.