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L.Subramanian*, P.Ramsubramaniyan, S.Kanda Kumar, S. Palanichamy, P.Solairaj


New era is an era of Novel Drug Delivery Systems. Formulation research is oriented towards increasing the efficacy of existing drug molecule through novel concepts of drug delivery. Losartan Potassium is an angiotensin receptor antagonist, used in the management of hypertension, which is a potential drug candidate for developing into Fast Dissolving Tablet System. It has low bioavailability due to its first pass metabolism. In the present work an attempt has been made to formulate and evaluate Fast Dissolving Tablet System of Losartan Potassium. The basic approach followed in this study was to incorporate a combination of superdisintegrants in optimum concentrations which can minimize disintegration time. The various superdisintegrants used in the present study were CCS, SSG, and CP. The concentrations of the superdisintegrants are 2.5, 3.5, and 5. Various batches of Fast Dissolving Tablet System were prepared by direct compression method and using conventional tablet machine. The formulated Fast Dissolving Tablet System were evaluated for various pre compression parameters and post compression parameters. All the batches of the formulations possessed required physicochemical parameters. The disintegration time of various formulations ranged from 21 to 26 seconds. In vitro drug release for various formulations ranges from 88.92 to 99.69 % end of 12 minutes.

Keywords: Fast dissolving tablets; Losartan Potassium; Direct compression; physicochemical parameters; Disintegration time; In vitro drug release; stability studies

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