Abstract

INSILICO, INVITRO ANTHELMINTIC POTENTIAL OF PETROSELINUM CRISPUM (MILL.) NYMAN EX AUCT ANON LEAVES AND STEM IN PHERETIMA POSTHUMA MODEL

Sanjukta Sainath Singh* and Bhagyalata Satapathy

ABSTRACT

The extracts of the plant Petroselinum crispum shows the anthelmintic effect and In-vitro anthelmintic activity was studied by Pheritima posthuma model by taking albendazole as standard. The plants were also tested for its anti-oxidant properties by DPPH and nitric oxide assay. In DPPH assay the ethanol extract showed a maximal inhibitory concentration of 64.32% at 1000 μg/ml and aqueous extract showed 60.46% at 1000 μg/ml. In nitric oxide assay the ethanol and aqueous extracts showed 68.45% and 65.42% at 1000 μg/ml. Further, the phytoconstituents reported in the P.crispum were docked against the tubulin target by in-silico docking studies. It was found that only albendazole and myrtenal showed interaction with the target protein.

Keywords: Anthelmintic, Anti-Oxidant, Ethanol Extract, In-Silico Docking, Lipinski rule.