Abstract

FORMULATION AND EVALUATION OF MATRIX TABLETS FOR DELIVERY OF METHYL PREDNISOLONE SPECIFICALLY TO THE COLON

Ravi Dnyandeo Hole* and Vishal Bharat Babar

ABSTRACT

The current study produced and assessed tamarind seed polyose and guar gum-based matrix tablets for the colon-targeted administration of methyl prednisolone acetate. The matrix tablets were made using the wet granulation procedure. The weight and medicine content of each pill were both consistent, with low SD values. Both the hardness and brittleness were within acceptable limits. According to the DSC & FTIR analyses, the drug is stable in the formulations. The uncoated tablets had a slightly rough surface compared to the smooth surfaces of the tablets coated with rosin and ERS, and the porous film that covered the surfaces of the PMMA-coated tablets. Utilising a dissolving rate test device in gastric and intestinal fluids, an in-vitro drug release investigation was carried out. Since the uncoated tablets did not
prevent the maximal amount of drug from being released in the physiological environment of the stomach and small intestine within 5 hours, they are not appropriate for targeted drug delivery to the colon. In contrast, tablets coated with Eudragit RS100 released a modest amount of the medication within 5 hours, and the majority of the medication was directed into the colon. As a result, in this study, Eudragit RS100 performed better as a coating material than rosin gum and PMMA. The integrity and transit of the T7 tablet, which demonstrated an acceptable release in vitro, were examined in rabbits. The produced tablet stayed intact for up to 11 hours, according to the results of in vivo roentgenography, and transit was clearly visible. The release of the drug was non-Fickian in nature.

Keywords: Colon targeting, Methyl Prednisolone Acetate, X - Ray study.