Abstract

A REVIEW ON SOLID DISPERSION

Kritika Thakur*, Meenu Nagpal, Geeta Aggarwal, Rupinder Kaur, Sukhdev Singh, Tapan Behl, Upendra Kumar Jain

ABSTRACT

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique represents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphousparticles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug.

Keywords: Poorly soluble drug; solid dispersion; solubility enhancement.