A REVIEW ON FORMULATION AND EVALUATION AN ANTIFUNGAL CREAM WITH KETOCONAZOLE BASED ON TRANSFEROSOMES
Utkarsh Singh*, Harshita Gupta and Anushka Verma
ABSTRACT
Gregor Cevc initially introduced the word "transfersome" & the idea it represented in 1991. A transfersome, in its widest sense, is any complex aggregate that is both extremely flexible and resistant to external stresses. Its optimal structure is a highly flexible vesicle, wherein a complex lipid bilayer encloses an aqueous core. Because local bilayer composition and form are mutually dependent, the vesicle may regulate and optimise itself. As a result, the transfersome can act as a drug carrier for sustained release of therapeutic medications and non-invasive targeted medication administration despite encountering a wide range of transport impediments. Because of its convenience and safety, transdermal administration is an attractive option in this context. Potential advantages include avoiding first-pass metabolism, maximising physiological and pharmacological response, minimizing undesirable side effects, using drugs with short half-lives, preventing drug level fluctuations, inter- and intra-patient variation, and improving patient convenience (Shaw et al., 1999). Several chemical and physical methods have been developed to boost the penetration enhancers' capacity to carry substances through the skin. Supplementing colloidal carriers such lipid vesicles (liposomes and proliposomes) and nonionic surfactant vesicles (niosomes and proniosomes) with enhancers, iontophoresis, and sonophoresis can improve drug delivery. Transdermal medication distribution was made easier with the creation of phospholipid vesicles (transsomes). The ultra-flexible membrane on these self-optimized aggregates makes it possible to reliably inject the medicine through the skin or into a vein... These vesicular transfersomes are far more elastic than regular liposomes, making them perfect for skin penetration. Transfersomes, seen in fig. 1, pass through the epidermal barrier by compressing along the intracellular sealing lipid of the stratum corneum. Because of the great vesicle deformability, mechanical stress from the environment might help promote the entrance in a self-adaptive fashion. By mixing the right proportions of surface-active chemicals, the membrane of transfersomes may be made more flexible. When used in nonocclusive conditions, transfersomes' flexible membrane allows them to migrate in accordance with the epidermis' natural water gradient. As a result, vesicle rupture is less likely to occur (Cevc et al, 1991).
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