Abstract

DESIGN AND DEVELOPMENT OF FLOATING ORAL INSITU GEL OF CURCUMIN LOADED SOLID DISPERSION

Sanjana M.*, Athulia S., Sibina Raihana A.P., Mohammed Hadique O. N., T. Subburaju and Kanaka V. S.

ABSTRACT

The present study was conducted with an aim to increase solubility and dissolution of curcumin by solid dispersion technology and to formulate it as stomach specific drug delivery. Curcumincoming from Curcuma longa which gives golden colour and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The solid binary system were prepared using drug polymer ratio (1:3, 1:5) by kneading method. PVPK 30 was also used as a polymer. The formulation ware characterized by phase solubility studies, particle size determination, FTIR studies, thin layer chromatography. The solubility of drug increased linearly with increase in polymer concentration. The gastroretentive drug delivery system is facing many challenges which can overcome by insitu gelling system. Formation of insitu gels depends upon temperature. pH change, ionic cross-linking and solvent exchanging from which drug get released in sustained and controlled manner. After incorporation of the solid dispersion into insitu gelling system, dark orange liquid preparation for oral use were obtained. The liquid floated within 5-7s and its floating was maintained for more than 12hrs in test medium. Amount of curcumin released from floating gel was expected within 12hrs depending upon the polymer composition. The incorporation of HPMC was found to retard the release of curcumin. The selected formulation (F1)) comprised of sodium alginate, HPMC calcium carbonate, sodium citrate, methyl paraben, propyl paraben, waterand Curcumin solid dispersion. The result demonstrated that newly formulated insitu gelling systems has the potential to be used for the stomach specified delivery of a poorly water soluble substance such as Curcumin. It enhanced bioavailability as well as gastroretention property of drug. So it can be used to treat gastric ulcers and other digestive disorders.

Keywords: Curcumin, Gastroretentive system, Insitu gelling, Solid dispersion, FTIR, Thin layer chromatography, PVPK30.