Abstract

DEVELOPMENT OF FORMULATION AND CHARACTERIZATION OF PRIMIDONE NIOSOMES FOR IMPROVED ANTI-CONVULSANT ACTIVITY

Karthick K., Jaisri S.*, Shanthi A. and Meena A.

ABSTRACT

Aim: Formulating Primidone in niosomal drug delivery system to minimize the dose and also to achieve sustained release for prolonged period of time. Place and Duration of study: The present work has been carried out between Jan 2023- July 2023, at K. K College of Pharmacy, Chennai- 600 122. Methodology: Primidone Niosomes was formulated by Thin Film Hydration Technique using Rotary flash evaporator. The formulated Niosomes were subjected to Pre-formulation studies, FT-IR, SEM analysis, Particle size and zeta potential, Entrapment efficiency, In-vitro drug release, In-vitro release kinetics, Stability study and Sterility studies. Result: FT-IR analysis revealed that the drug Primidone was compatible with all the excipients used in the formulation. Microscopic examination revealed that the vesicle diameter complies within the range of 100 to 300 nm. Particle size and zeta potential studies reveals that F-VIII formulations were complied with the limit range. The entrapment efficiency of drug in F-VIII showed that span 60 is the more suitable surfactant along with cholesterol for enhancing maximum entrapment for the drug Primidone. F-VIII showed 96.15% of drug release within 22 hours. The optimized formulation F-VIII was subjected to release kinetics and its follows zero order kinetics. Stability study was carried out for formulation F-VIII and it remains stable at 4°c. Sterility tests were performed for the optimized formulations which found to be sterile. These results showed that Primidone Niosomes has sustained release up to 22 hours.

Keywords: Niosomes, Thin film hydration technique, Epilepsy, Primidone.