Abstract

TO STUDY OF THE EFFECTIVENESS OF CARICA PAPAYA LEAF EXTRACT AS A PLATELET BOOSTER

*Dr. S. Ravichandran M. Pharm., Ph.D, V. Saraladevi, M. Pharm., Phd, Arun Kumar S., Muniraj U., Praveen R. Tamilarasan V. and Vimal Kumar K.

ABSTRACT

Popular and commercially significant plant Carica papaya leaf has been investigated for its potential as a platelet stimulant. Papain, chymopapain, glycyl endopeptidase, and caricain are four cysteine endopeptidases that are abundantly found in latex, which is secreted by lactifers in the plant. The leaves include the glucoside carposide and the alkaloid carpaine. Alkaloids are frequent carboxylic acid salts that are organic nitrogenous bases and heterocyclic compounds found in plants. According to reports, carpine can depress the central nervous system and produce bradycardia. Blood cells called platelets, also known as thrombocytes, react to bleeding caused by blood vessel damage and take part in both innate and adaptive intravascular immune responses. They are created from totipotent marrow stem cells, and thrombopoietin controls their production. In addition to having anti-tumour and immunomodulatory actions, Carica papaya leaf extract has been shown to raise platelet count and hematocrit levels in dengue fever patients. Alkaloids, glycosides, tannins, saponins, and flavonoids are among the active ingredients found in leaf extract. The carpaine works by encouraging the bone marrow to create more megakaryocytes, which are in charge of producing and aggregating platelets in blood circulation. Papaya leaf juice boosts the expression of the CD110 receptor on megakaryocytes, successfully treating thrombocytopenia brought on by chemotherapy. Additionally, it keeps hematocrit levels normal and lessens platelet deterioration. Although studies on mice did not reveal any negative consequences, greater dosages may result in possible liver damage. In Sri Lanka, the extract & potential for treating dengue and promoting wound healing has been studied.

Keywords: According to reports, carpine can depress the central nervous system and produce bradycardia.