Abstract

A REVIEW OF TIROFIBAN'S SAFETY AND EFFICACY IN THE MANAGEMENT OF STROKE: CURRENT INSIGHTS AND FUTURE PROSPECTS

Fathima Nashiya*, Hina Aisha, Saba Farooqui, Zuha Shyma, Suha Zulekha and Sajan Francis P.

ABSTRACT

Stroke is a leading cause of mortality and morbidity worldwide, necessitating the continuous exploration of novel therapeutic interventions to improve patient outcomes. One such intervention under investigation is the use of tirofiban, a glycoprotein IIb/IIIa receptor antagonist commonly used in the management of acute coronary syndromes. Preclinical studies have demonstrated the potential neuroprotective effects of tirofiban, including the inhibition of platelet aggregation, reduction of inflammation, and improvement of microcirculation. Clinical trials evaluating tirofiban in acute ischemic stroke have reported conflicting findings regarding its efficacy in improving functional outcomes and reducing mortality. Some studies have demonstrated potential benefits in terms of recanalization rates, reduced infarct size, and improved neurological recovery, while others have failed to show significant clinical improvements. The optimal dosing regimen, timing of administration, and patient selection criteria remain areas of ongoing investigation and debate. Safety considerations of tirofiban include the risk of bleeding complications, particularly in combination with thrombolytic therapy. Adverse events, such as major hemorrhage or allergic reactions, should be carefully monitored. Risk stratification, appropriate patient selection, and individualized treatment plans are crucial factors to optimize the benefit-risk profile of tirofiban in stroke patients. Tirofiban holds promise as a therapeutic option for stroke management, particularly in ischemic stroke. Further investigation, including larger randomized controlled trials, is necessary to establish the optimal use, dosing, and patient selection criteria for tirofiban in stroke.

Keywords: Tirofiban, endovascular treatment, Recanalization, Functional outcome.