Abstract

RECENT ADVANCEMENTS IN GASTRO-RETENTIVE DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW

Amliwala Hamza Ilyas*, Prof. Rehan Deshmuhk, Dr. G.J. Khan, Sayyed Ahamad Sayyed Kaleem, Shah Afrin Salim and Mansoori Safwan Salim

ABSTRACT

In recent years, there has been a concerted effort to enhance the effectiveness of oral drug dosage forms by improving their bioavailability. One approach that has gained traction is the utilization of gastro retentive drug delivery systems (GRDDS) to optimize the therapeutic out comes of drugs with specific characteristics. These medications may have restricted absorption potential due to a small absorption window, susceptibility to alkaline pH, solubility in acidic circumstances, or confined activity within the stomach. This review investigates the physiological state of the stomach as well as the various aspects impacting GRDDS performance. Notably, contemporary gastrointestinal technologies like expandable super porous hydrogel, Bio/Mucoadhesive systems, magnetic systems, and low- and high-density systems are evaluated, weighing their respective advantages and drawbacks. The assessment also encompasses critical in vivo and in vitro evaluation criteria for various GRDDS, underscoring their practical applications. The review also delves into the potential applications of these advancements, emphasizing the imperative to delay gastric emptying across both fasting and fed states. The insights shared in this review can serve as a valuable resource for formulation scientists endeavoring to create effective GRDDS. Specifically, the article focuses on the formulation developments of gastric retentive drug delivery systems, emphasizing prolonged drug residence times and improved oral bioavailability. Additionally, the review addresses the context of H. pylori infection, examining patented delivery systems and commercially available products designed for gastric retention. The advantages of these systems, along with their future potential, are explored.

Keywords: Gastro retentive drug delivery systems (GRDDS), Oral bioavailability enhancement, Anatomy and Physiological state of the stomach, Gastric retention technologies, In vitro evaluation, H. pylori treatment, Marketed products.