Abstract

REVIEW ON THALIDOMIDE

*Vijayshri Katare, Dr. Pawan Awhad, Deokar Kajal, Jadhav Shital, Aher Monika, Pathare Shivam and Zalte Gokul

ABSTRACT

Nearly 60 years ago thilodomide was prescribed to treat morning sickness pregnant woman what followed was the biggest man -made medical disaster ever where over10,000 children were born with a range of severe adebilitating malformations. Despite this the drug is now used successfully treat a range of adult condition, including multiple myeloma and complications of leprosy. Tragically, a new generation of thalidomide damaged children has been identified in brazil. Yet, how thalidomide caused it's devastating effects in the forming embryo remains unclear. However, studies in the past few years have greatly enhanced our understanding of the molecular mechanisms the drug. This review will look at the history of the drug, and the range and type of damage the drug caused, and outline the mechanism of action the drug uses including recent molecular advances and new finding. Some of the remaining challenges facing thalidomide biologists are also discussed. Birth defects research(part c) 105:140-156, 2015. C 2015 the authors birth defects research part c: embryo today: reviews published by Wiley periodicals, lnc.

Keywords: Angiogenesis; reactive oxygen species, cell death; cereblon; actinytoskeleton; limb development; fgf8; shh;phocomelia; vascular transition.