Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE TABLETS OF CLOPIDOGREL

Prasanthi Teella*, Hema Kiranmayi Budida, Vineela Penugonda, Anju K. Abraham,
Tirumala Devi Siriki and Laharika Vadrevu

ABSTRACT

Oral administration is the most convenient and preferred means of any drug delivery to the systemic circulation. Oral controlled release drug delivery systems (CRDDS) have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages. oral sustained-controlled release formulations is an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the systemic circulation for a long time. Clopidogrel is an oral thienopyridine - class antiplatelet agent used to inhibit blood clots in coronory artery disease, peripheral vascular disease, and to prevent myocardial infraction. In the present work, an attempt has been made to formulate GRDDS of Clopidogrel using different mucoadhesive polymers like Hydroxy propyl methyl cellulose K100M (HPMC K100M), Sodiun carboxy methyl cellulose (NaCMC), Carbopol 934P and Poly vinyl pyrrolidone K30 (PVP K30) in order to prolong the drug release, and to impart mucoadhesive properties to the controlled release tablet formulations. Total 13 formulations are prepared, out of all formulations F13 containing both HPMC K100 and Na CMC gave the best results that is 99.9% in the time period of 16 hours. All the formulations passed the pre and post compression studies.

Keywords: Controlled release drug delivery, Gastrointestinal tract, Clopidogrel, Hydroxy propyl methyl cellulose, Sodiun carboxy methyl cellulose, Poly vinyl pyrrolidone, Mucoadhesive.