Abstract

EVALUATION OF ANTIPARKINSONIAN ACTIVITY OF ETHANOLIC EXTRACT OF CAESALPINIA PULCHERRIMA ON HALOPERIDOL INDUCED PARKINSONISM IN WISTAR RATS

Potladurthi Manohar, *C. Bhuvaneswara Rao and Dr. P. V. Madhava Reddy

ABSTRACT

In the present study, we evaluated anti-Parkinson‟s activity of ethanolic extract of Caesalpinia pulcherrima (EECP) leaves in haloperidol induced experimental animal models. In this study, effects of Caesalpinia pulcherrima (200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, and locomotor activity and its effects on neurochemical parameters (CAT, SOD, and GSH) in rats. The experiment was designed by giving haloperidol to induce catalepsy to induce Parkinson‟s disease-like symptoms. The increased cataleptic scores (induced by haloperidol) were significantly found to be reduced, with the EECP at a dose of 200 and 400 mg/kg (p.o.). Haloperidol significantly induced motor dysfunction (muscle rigidity and hypolocomotion). Haloperidol administration showed significant increase in lipid peroxidation level and depleted superoxide dismutase, catalase, and reduced glutathione level. Daily administration of EECP (400 mg/kg) significantly improved motor performance and also significantly attenuated oxidative damage. Thus, the study proved that Caesalpinia pulcherrima treatment significantly attenuated the motor defects and also protected the brain from oxidative stress.

Keywords: Caesalpinia pulcherrima, Haloperidol, anti parkinsons activity, Catalase.