Abstract

FORMULATION AND IN-VITRO EVALUATION OF TRIAMCINOLONE ACETONIDE BUCCAL PATCHES

Pulindala Pravallika*, Angilicam Avinash and Dr. S. Sujatha

ABSTRACT

Triamcinolone is a corticosteroid used to treat different fiery conditions in the body from unfavorably susceptible rhinitis to intense intensifications of various sclerosis. Triamcinolone can be utilized as a onetime aide therapy of osteoarthritic knee pain, or first line as a skin therapy of corticosteroid responsive dermatoses. In present study buccal drug delivery of Triamcinolone was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of buccal patches was developed by using polymers Methocel K15M, Methocel K100M and Sodium CMC. Buccal patches were prepared by employing solvent casting method. Propylene glycol was selected as plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F9, and all the formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake and Moisture content and all the results were found to be were found to be within the pharmacopeial limits, in-vitro drug release studies by using dialysis membrane. Among all the 9 formulations F2 with 97.06% drug release is the optimized formulation.

Keywords: Triamcinolone acetonide, buccal patches, Methocel K15M, Methocel K100M and Sodium CMC.