Abstract

AN UPDATED REVIEW ON BIOANALTICAL METHOD: IT’S DETERMIANATION AND VALIDATION

*Jagdale R.C., Prasad Satalkar and Sanket N. Dashpute

ABSTRACT

The development of sound bioanalytical system( s) is of consummate significance during the preclinical and clinical stages of medicine development. thus, it's generally accepted that sample medication and system confirmation are needed to demonstrate the performance of the system and trust ability. Recent times have witnessed the preface of several high – quality review papers into the literature covering colourful scientific and specialized aspects of bioanalysis. Now it's extensively accepted that bioanalysis is an integral part of the pharmacokinetic/ pharmacodynamic characterization of new chemical reality from the time of its discovery and leading to its request authorization. The present review Concentrated on colourful birth ways like liquid- liquid birth, solid phase birth and protein rush which play important part in sample medication and discovery by RP HPLC. In this review composition, we're proposed to add some points regarding bioanalytical system development and confirmation parameter, salutary to quality assurance to determine the medicine, Attention and its metabolite.

Keywords: Bioanalytical method validation, extraction techniques, bioanalysis, Method development.