Abstract

DIFFERENCES IN LIPID PROFILE WITH INTERNATIONAL PRODUCT OF SIMVASTATIN AND LOCAL PRODUCT IN PATIENTS WITH PRIMARY HYPERLIPIDEMIA

Naveed Ali Siddiqui, MBBS, MPhil, Tahira Perveen, Syed Asif Jahanzeb Kazmi, Aziza Khanum, Ambreen

ABSTRACT

Objective: To compare the changes in lipid profile in patients with primary hyperlipidemia using international and local product of the lipid lowering drug, Simvastatin. Material and Methods: The study was conducted at Surgeon Munawar Memorial Hospital, Karachi in year 2009 -2011. The study was designed to evaluate the effects of simvastatin on lipid profile, and to compare the lipid lowering efficacy of international and local product of simvastatin in patients with primary hyperlipidemia. Fifty patients with abnormal lipid profile were included in the study (age 30-70 years). Patients were divided into two groups (25 patients each). Group A was orally administered with international product of simvastatin (10 mg)/day for 4 weeks and in group B, patients were orally administered with local product of simvastatin (10 mg)/day for 4 weeks. Results: The Cholesterol, Triglyceride (TG), High density lipoprotein (HDL) and Low density lipoprotein (LDL) were estimated in the serum of patients before and after treatment with international and local product of simvastatin (10mg/day). After the treatment serum Cholesterol, Triglyceride and Low density lipoprotein were decreased in both groups, both drugs were well tolerated by the subjects without any serious side effects. Conclusion: On the basis of this study we concluded that both international and local product of simvastatin are equally effective.

Keywords: Lipid profile, Hyperlipidemia, Local & International product, Simvastatin.