Abstract

A REVIEW ON ROLE OF CYANOCOBALAMIN (VITAMIN B12)

*Shital Wagh, Dr. Pawan Aavhad and Netra Shelke

ABSTRACT

Cobalamin (Cbl), also known as vitamin B12, is an indispensable watersoluble molecule. As far as it is known at present, its function is restricted to cofactorial activity for only two enzymes. However, they are crucial for anabolic and catabolic processes of the body with more emphasis for strong cell replication events like hematopoiesis and tissues expansions. Moreover, Cbl exhibits a central function in neuronal health such as the maintenance of the myelin sheath. Even if a balanced diet is able to provide a sufficient amount of Cbl, some diseases can lead to a vitamin deficiency status. The comprehension of the complexity of the finely regulated transport and endocellular trafficking can help to prevent a shortage, providing efficient diagnostic tools and the adequate dosage of supplementation, if it is needed. Whilst in conventional medical practice B12 deficiency is generally treated with intramuscular injections, it is generally accepted that oral (per os) administration at a high dose is as effective at improving B12 status. Diagnosis of B12 deficiency is complicated by the fact that levels of B12 in the blood are maintained even when stores are low at the expense of tissue levels. Where a deficiency is suspected but serum levels are normal, other markers can be used to confirm a deficiency

Keywords: Methotrexate, nephrotoxicity, cyanocobalamin, antioxidants, rat, histopathology.